1421330-73-5Relevant articles and documents
Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: Design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)- 9H -purines as prodrugs of O6-benzylguanine
Zhu, Rui,Baumann, Raymond P.,Penketh, Philip G.,Shyam, Krishnamurthy,Sartorelli, Alan C.
, p. 1355 - 1359 (2013)
O6-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein which removes alkyl groups from the O-6 position of guanine, thereby providing strong resistance to anticancer agents which alkylate this position. The clinical usefulness of th