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  • 1421330-83-7 Structure
  • Basic information

    1. Product Name: C12H11Br3N2O2
    2. Synonyms: C12H11Br3N2O2
    3. CAS NO:1421330-83-7
    4. Molecular Formula:
    5. Molecular Weight: 454.944
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1421330-83-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C12H11Br3N2O2(CAS DataBase Reference)
    10. NIST Chemistry Reference: C12H11Br3N2O2(1421330-83-7)
    11. EPA Substance Registry System: C12H11Br3N2O2(1421330-83-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1421330-83-7(Hazardous Substances Data)

1421330-83-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1421330-83-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,3,3 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1421330-83:
(9*1)+(8*4)+(7*2)+(6*1)+(5*3)+(4*3)+(3*0)+(2*8)+(1*3)=107
107 % 10 = 7
So 1421330-83-7 is a valid CAS Registry Number.

1421330-83-7Downstream Products

1421330-83-7Relevant articles and documents

Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors

Chen, Shi-Chao,Qiu, Guo-Liang,Li, Bo,Shi, Jing-Bo,Liu, Xin-Hua,Tang, Wen-Jian

, p. 194 - 204 (2018/02/14)

BuChE inhibitors play important roles in treatment of patients with advanced Alzheimer's disease (AD). A series of tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one derivatives were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylch

Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors

Tong, Xu,Chen, Rui,Zhang, Tong-Tian,Han, Yan,Tang, Wen-Jian,Liu, Xin-Hua

, p. 515 - 525 (2015/01/30)

Thirty seven novel 2-pyrazoline-1-ethanone derivatives were designed, synthesized and evaluated as selective hMAO inhibitors. Among them, compounds 7h (IC50 = 2.40 μM) and 12c (IC50 = 2.00 μM) exhibited best inhibitory activity and selectivity against hMAO-A, surpassing that of the positive control Clorgyline (IC50 = 2.76 μM). Based on selective activity of hMAO-A, SAR analysis showed that the order of N1 substituent contribution was bromo (3) > piperidinyl (4) > morpholinyl (5) > imidazolyl (6), and compounds with electron-withdrawing substituents (-F, -Cl) at C3 or C5 phenyl ring of 2-pyrazoline nucleus dedicated stronger MAO-A inhibitory activity. Molecular docking showed that compounds 7h and 12c were nicely bound to hMAO-A via two hydrogen bonds (SER209, GLU216), one Pi-Pi interaction and three hydrogen bonds (SER209, GLU216, TYR69), one Sigma-Pi interaction, respectively. In addition, the substituent at C3 position of 2-pyrazoline with the N1 acetyl has little effect on MAO-A inhibitory activity. These data support further studies to assess rational design of more efficiently selective hMAO inhibitors in the future.

Novel coumarin-dihydropyrazole thio-ethanone derivatives: Design, synthesis and anticancer activity

Wu, Xiao-Qin,Huang, Cheng,Jia, Ying-Ming,Song, Bao-An,Li, Jun,Liu, Xin-Hua

, p. 717 - 725 (2014/03/21)

A series novel 1-(3-substituted-5-phenyl-4,5-dihydropyrazol-1-yl)-2-thio- ethanone derivatives as potential telomerase inhibitors were designed and synthesized. The bioassays demonstrated that compounds 4a, 4f, 4j and 7b, 7d occupied high antiproliferative activity against SGC-7901, MGC-803, Bcap-37 and HEPG-2 cell lines. By a modified TRAP assay, some title compounds were tested against telomerase, and compound 4f showed the most potent inhibitory activity with IC50 value at 0.92 ± 0.09 μM. The mechanism of antitumor action indicated that title compounds 4f and 7b could suppress cell proliferation through inducing cell cycle arrest in G0/G1 phase.

Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5- tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors

Liu, Xin-Hua,Jia, Ying-Ming,Song, Bao-An,Pang, Zhi-Xiang,Yang, Song

, p. 720 - 723 (2013/03/13)

Eight novel 4,5-tetrahydropyrazolo[1,5-d][1,4]oxazepine derivatives have been synthesized and purified to be screened for anticancer activity. By a modified TRAP assay, some titled compounds were tested against telomerase, and compound 4a showed the most potent inhibitory activity with IC50 value at 0.78 ± 0.22 μM. Western blot assays showed that compounds 4a and 4b could inhibit expression of Cyclin D1, TERT, phospho-AKT and PI3K/AKT pathway.

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