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1421373-65-0

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Product FOB Price Min.Order Supply Ability Supplier
AZD-9291/1421373-65-0/99%purity in stock/best price
Cas No: 1421373-65-0
No Data 1 Gram Metric Ton/Day Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd Contact Supplier
AZD9291 CAS NO.1421373-65-0 high purity 99% in stock
Cas No: 1421373-65-0
No Data No Data Metric Ton/Day CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD Contact Supplier
AZD9291 purity 99.5% min/Osimertinib Manufacturer/Mereletinib in
Cas No: 1421373-65-0
USD $ 1.0-2.0 / Kilogram 25 Kilogram 1 Metric Ton/Month Hubei DiBo chemical co., LTD Contact Supplier
AZD-9291
Cas No: 1421373-65-0
USD $ 1.0-1.0 / Gram 1 Gram 100 Gram/Month Wuhan Sunrise Technology development company limited Contact Supplier
AZD9291
Cas No: 1421373-65-0
No Data No Data Metric Ton/Day ningbo easun bio-tech co., ltd Contact Supplier
lower price AZD9291(1421373-65-0) supply CAS NO.1421373-65-0
Cas No: 1421373-65-0
USD $ 500.0-600.0 / Metric Ton 5 Metric Ton 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Manufacturer supply Osimertinib (AZD9291) CAS 1421373-65-0 with good quality
Cas No: 1421373-65-0
USD $ 10.0-30.0 / Gram 50 Gram 100 Kilogram/Week Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Osimertinib (AZD9291)
Cas No: 1421373-65-0
No Data No Data Metric Ton/Day Shenzhen READLINE Technology Co., Ltd. Contact Supplier
Osimertinib
Cas No: 1421373-65-0
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Mereletinib (AZD-9291)
Cas No: 1421373-65-0
No Data 500 Gram 500 Kilogram/Month Shanghai Rochi Pharmaceutical Co., Ltd. Contact Supplier

1421373-65-0 Usage

Uses

AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.[Cayman Chemical]

References

http://www.medkoo.com/products/6711
https://en.wikipedia.org/wiki/Osimertinib
https://www.drugbank.ca/drugs/DB09330

Description

AZD-9291 (Mesylate), also known as Osimertinib, belongs to a third-generation EGFR (epidermal growth factor receptor) inhibitor. It can be used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in case when the cancer cells carry specific mutations (such as T790M) in the epidermal growth factor receptor. It takes effect through directly binding to the certain mutant forms of EGFR (T790M, L858R, and exon 19 deletions) that are frequently found in NSCLC, further causing poor prognosis for late-stage disease. Since it spares wild type EGFR during therapy, it has only limited toxicity.

Uses

AZD-9291 (Osimertinib) is a oral, third generation, small-molecule epidermal growth factor receptor (EGFR) inhibitor and antineoplastic agent. In addition, it is a Cytochrome P450 3A inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 1A2 Inducer, and Breast Cancer Resistance Protein Inhibitor. It is used for the treatment of advanced non-small cell lung cancer (NSCLC) where mutant EGFR form (such as T790M) is often presented. Through suppressing the EGFR-mediated signalling, it cause cell death and inhibit tumour growth in related cancer cells. 

Definition

ChEBI: A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treat ent of EGFR T790M mutation positive non-small cell lung cancer.

1421373-65-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name AZD9291

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1421373-65-0 SDS

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