142141-40-0

Basic information

• Product Name: Benzenemethanamine, 2-amino-N-ethyl- (9CI)
• Synonyms: Benzenemethanamine, 2-amino-N-ethyl- (9CI)
• CAS NO: 142141-40-0
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22086
• Product Categories: AMINEPRIMARY
• Mol File: 142141-40-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanamine, 2-amino-N-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2-amino-N-ethyl- (9CI)(142141-40-0)
• EPA Substance Registry System: Benzenemethanamine, 2-amino-N-ethyl- (9CI)(142141-40-0)

Safety Data

• Hazardous Substances Data: 142141-40-0(Hazardous Substances Data)

Upstream product

• 4403-69-4 2-amino-1-benzylamine 
• 85690-51-3 N-(2-aminobenzyl)acetamide 
• 57707-12-7 Ethyl-[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amine 
• 75-04-7 ethylamine 
• 552-89-6 2-nitro-benzaldehyde 
• 186797-08-0 N-(2-nitrobenzyl)ethylamine 
• 4141-08-6 2-Amino-N-methylbenzamid 

Relevant articles and documents

Regioselective N-alkylation of 2-aminobenzylamine via chelation to 9- BBN

A selective synthesis of 2-amino-N-alkylbenzylamines by direct mono alkylation of 2-aminobenzylamine is achieved by a potassium tert- butoxide/alkyl halide treatment of a 9-BBN amine-aminoborane chelate.

Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine

A straightforward strategy for the synthesis of dihydroquinazolines is presented, which allows for the preparation of 3,4- and 1,4-dihydroquinazolines with different substitution patterns from 2-aminobenzylamine (2-ABA) as common precursor. The required functionalization of both amino groups present in 2-ABA was achieved by different routes involving selective N-acylation and cesium carbonate-mediated N-alkylation reactions, avoiding protection/deprotection steps. The heterocycles were efficiently synthesized in short reaction times by microwave-assisted ring closure of the corresponding aminoamides promoted by ethyl polyphosphate (PPE).

NEW COMPOUNDS

The present invention encompasses compounds of general Formula (I) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation