142168-51-2

Upstream product

• 89779-30-6 diethyl 3-amino-2-cyano-2-pentene-1,5-dicarboxylate 
• 103-72-0 phenyl isothiocyanate 
• 1205-74-9 4-bromo-3-oxo-N-phenylbutanamide 
• 142168-50-1 ethyl 3-amino-2-cyano-3-(2'-formanilidoacetyl-3'-hydroxy-5'-phenylaminothiophen-4'-yl)-acrylate 

Downstream Products

• 142168-52-3 4-amino-3-cyano-5-hydroxy-6-(α-phenylhydrazo-formanilidoacetyl)-2-oxo-1-phenyl-thieno<2,3-b>pyridine 
• 142168-53-4 9-amino-8-cyano-4,7-dioxo-3-formanilido-6-phenyl-pyrido<2,3:2',3'>thieno<4,5-c>pyridazine 

Relevant academic research and scientific papers

Phenyl Isothiocyanate in Heterocyclic Synthesis: Novel Synthesis of Thiazoles, Thienopyridine, Thiophene and Thienopyridazine Derivatives

The enamino nitriles 1 and 2 react with phenyl isothiocyanate followed by cyclization with α-haloketones 3 and 10 to afford in each case the thiazole 5, thiophene 11 and the thienopyridine derivatives 19 and 21.Chemical and spectroscopic evidences