1421680-22-9Relevant academic research and scientific papers
Na2S-promoted reduction of azides in water: Synthesis of pyrazolopyridines in one pot and evaluation of antimicrobial activity
Kale, Ashok,Medishetti, Nagaraju,Kanugala, Sirisha,Ganesh Kumar,Atmakur, Krishnaiah
, p. 3186 - 3194 (2019)
Reduction of various azides using Na2S has been accomplished in water, and, in situ, the resulting amines on reaction with various ketones lead to pyrazolo[3,4-b]pyridines in one pot. Thus, a number of new trifluoromethyl-substituted pyrazolo[3,4-b]pyridine compounds have been prepared and screened for antimicrobial activity against different Gram-positive and Gram-negative strains. A good number of compounds, 4a, 4b, 4d, 4f, 4i, 4k, 4l, 4m, 4r and 4s, were found to possess promising activity. Notably, Na2S on hydrolysis in water generates H2S and NaOH, which facilitate the reduction of azides followed by intramolecular cyclization leading to the title compounds. To the best of our knowledge, this is the first report of the synthesis of the title compounds in aqueous medium in a one-pot reaction.
Synthesis, characterisation and antimicrobial activity of 3-methyl-6-(aryl)-1-phenyl-1Hpyrazolo[ 3,4-b]pyridine
Girisha,Kalluraya, Balakrishna,Vidyashree Jois
, p. 1767 - 1770 (2013/02/23)
A series of 3-methyl-6-(aryl)-1-phenyl-1H-pyrazolo[3,4- b]pyridine have been synthesized in one step by treating 5-azido- 3-methyl-1-phenyl-1H-pyrazol- 4-carboxaldehyde with suitably substituted acetophenones in basic medium. This reaction is a good examp
