1421703-70-9

Basic information

• Product Name: tert-butyl 4-((4,5-dichloro-2-nitrophenyl)amino)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-((4,5-dichloro-2-nitrophenyl)amino)piperidine-1-carboxylate
• CAS NO: 1421703-70-9
• Molecular Weight: 390.266
• Mol File: 1421703-70-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-((4,5-dichloro-2-nitrophenyl)amino)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-((4,5-dichloro-2-nitrophenyl)amino)piperidine-1-carboxylate(1421703-70-9)
• EPA Substance Registry System: tert-butyl 4-((4,5-dichloro-2-nitrophenyl)amino)piperidine-1-carboxylate(1421703-70-9)

Safety Data

• Hazardous Substances Data: 1421703-70-9(Hazardous Substances Data)

Upstream product

• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 

Downstream Products

• 1421703-82-3 tert-butyl 4-((2-amino-4,5-dichlorophenyl)amino)piperidine-1-carboxylate 
• 1421703-64-1 C₂₅H₃₁Cl₂N₅O 

Relevant articles and documents

Optimization of a novel series of TRPV4 antagonists with in vivo activity in a model of pulmonary edema

High-throughput screening and subsequent hit optimization identified 1-piperidinylbenzimidazoles, exemplified by compound 1, as TRPV4 inhibitors. Lead optimization identified potent TRPV4 blocker 19, which has good target activity and pharmacokinetic properties. Inhibitor 19 was then profiled in an in vivo rat model, demonstrating its ability to inhibit TRPV4-mediated pulmonary edema.

SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS

The invention provides -opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.