1421705-01-2Relevant academic research and scientific papers
Ditopic ligands featuring [P,S], [P,P] or [P,B] chelating pockets housed on a protected o-hydroquinone core
Chuong, Rose,Luck, Kyle A.,Luck, Rudy L.,Nguyen, Lillian P.,Phan, Diane,Pignotti, Louis R.,Urnezius, Eugenijus,Valente, Edward J.
, p. 45 - 50 (2013)
1,2-Dibromo-4,5-dimethoxybenzene was explored as a platform for the buildup of ditopic ligands. Low temperature reactions with n-butyllithium followed by quenches with various electrophiles led to the syntheses (2-bromo-4,5- dimethoxyphenyl)diphenylphosphine (1), (4,5-dimethoxy-2-(methylthio)phenyl) diphenylphosphine (2), 1,2-bis(diphenylphosphino)-4,5-dimethoxybenzene (3), and (2-(dicyclohexylboryl)-4,5-dimethoxyphenyl)diphenylphosphine (4). Oxidation of 3 produced 1,2-bis(diphenylphosphoryl)-4,5-dimethoxybenzene (5). All compounds were characterized by multinuclear (1H/13C/ 31P{1H}) NMR spectroscopy and by high resolution mass spectrometry. In addition, single crystal X-ray diffraction characterizations of 1, 3, 4, and 5 were also carried out. Reactivity of o-phosphinophenylborane 4 toward molecular hydrogen was also probed.
