1421706-58-2Relevant academic research and scientific papers
Direct ortho-arylation of ortho-substituted benzoic acids: Overriding Pd-catalyzed protodecarboxylation
Arroniz, Carlos,Ironmonger, Alan,Rassias, Gerry,Larrosa, Igor
, p. 910 - 913 (2013)
ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.
