1421753-41-4Relevant academic research and scientific papers
Copper-Catalyzed Annulation Cascades of Alkyne-Tethered α-Bromocarbonyls with Alkynes: An Access to Heteropolycycles
Liu, Bang,Yu, Jiang-Xi,Li, Yang,Li, Jin-Heng,He, De-Liang
, p. 2129 - 2132 (2018)
We here describe a new Cu-catalyzed annulation cascade of alkyne-tethered α-bromocarbonyls with common alkynes for the synthesis of various heteropolycycle frameworks, including 1H-benzo[de]quinolin-2(3H)-ones, 4H-dibenzo[de,g]quinolin-5(6H)-one, and benzo[de]chromen-2(3H)-one, which were constructed with high selectivity. This was achieved by two-component annulation cascades, rather than atom-transfer radical cyclization (ATRC), with alkyne-tethered α-bromocarbonyls for one-step accessing heteropolycycles via C-Br bond split, intramolecular cyclization, intermolecular [4 + 2] annulation, and aryl C(sp2)-H functionalization cascades.
Silver-catalyzed incorporation of carbon dioxide into o-alkynylaniline derivatives
Ishida, Tomonobu,Kikuchi, Satoshi,Tsubo, Tatsuyuki,Yamada, Tohru
supporting information, p. 848 - 851 (2013/03/28)
Benzoxazine-2-one derivatives are important heterocycle structures because of their various pharmaceutical activities, though their synthetic methods had been limited. In some cases, toxic reagents, such as phosgene or carbon monoxide, are required. It was found that a silver catalyst successfully promoted the incorporation of CO2 into o-alkynylanilines to afford the corresponding benzoxazine-2-ones bearing Z exo-olefin via 6-exo-dig cyclization at the activated C-C triple bond.
