1421765-97-0Relevant academic research and scientific papers
A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus aspergillus fumigatus
Yin, Wen-Bing,Baccile, Joshua A.,Bok, Jin Woo,Chen, Yiming,Keller, Nancy P.,Schroeder, Frank C.
, p. 2064 - 2067 (2013)
Small molecules (SMs) play central roles as virulence factors of pathogenic fungi and bacteria; however, genomic analyses suggest that the majority of microbial SMs have remained uncharacterized. Based on microarray analysis followed by comparative metabolomics of overexpression/knockout mutants, we identified a tryptophan-derived iron(III)-complex, hexadehydro-astechrome (HAS), as the major product of the cryptic has nonribosomal peptide synthetase (NRPS) gene cluster in the human pathogen Aspergillus fumigatus. Activation of the has cluster created a highly virulent A. fumigatus strain that increased mortality of infected mice. Comparative metabolomics of different mutant strains allowed to propose a pathway for HAS biosynthesis and further revealed cross-talk with another NRPS pathway producing the anticancer fumitremorgins.
