1421840-16-5

Basic information

• Product Name: (3R)-5-chloro-8-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-7-carboxylic acid
• CAS NO: 1421840-16-5
• Molecular Weight: 270.669
• Mol File: 1421840-16-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R)-5-chloro-8-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-5-chloro-8-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-7-carboxylic acid(1421840-16-5)
• EPA Substance Registry System: (3R)-5-chloro-8-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-7-carboxylic acid(1421840-16-5)

Safety Data

• Hazardous Substances Data: 1421840-16-5(Hazardous Substances Data)

Upstream product

• 1100758-09-5 5-chloro-2-methoxybenzene-1,3-dicarboxylic acid 
• 15448-47-2 (R)-propylene oxide 
• 14804-27-4 4-chloro-2,6-dimethylphenyl methyl ether 
• 17026-49-2 4-chloro-2,6-bis(hydroxymethyl)phenol 
• 6641-05-0 2,6-bis-hydroxymethyl-4-chloro-anisole 
• 1123-63-3 2,6-dimethyl-4-chlorophenol 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 19165-63-0 (R)-(-)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-(1H)-2-benzopyran-7-carboxylic acid 

Relevant articles and documents

Efficient synthesis of (R)-ochratoxin alpha, the key precursor to the mycotoxin ochratoxin A

Two new routes for the synthesis of enantiomerically pure ochratoxin alpha ((3R)-OTα) are presented, which is the key intermediate for the synthesis of ochratoxin A (OTA) by coupling reaction with the amino acid l-phenylalanine. The key step of both routes is the one pot directed ortho-metalation/alkylation/ lactonization of unprotected and suitably functionalized aromatic carboxylic acids, using lithium tetramethylpiperidide (LTMP) and (R)-propylene oxide.