1421840-57-4Relevant academic research and scientific papers
General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse P-Stereogenic Secondary Phosphine Oxides
Han, Zhengxu S.,Wu, Hao,Xu, Yibo,Zhang, Yongda,Qu, Bo,Li, Zhibin,Caldwell, Donald R.,Fandrick, Keith R.,Zhang, Li,Roschangar, Frank,Song, Jinhua J.,Senanayake, Chris H.
, p. 1796 - 1799 (2017)
A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alcohol templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis.
Efficient asymmetric synthesis of P -chiral phosphine oxides via properly designed and activated benzoxazaphosphinine-2-oxide agents
Han, Zhengxu S.,Goyal, Navneet,Herbage, Melissa A.,Sieber, Joshua D.,Qu, Bo,Xu, Yibo,Li, Zhibin,Reeves, Jonathan T.,Desrosiers, Jean-Nicolas,Ma, Shengli,Grinberg, Nelu,Lee, Heewon,Mangunuru, Hari P. R.,Zhang, Yongda,Krishnamurthy, Dhileep,Lu, Bruce Z.,Song, Jinhua J.,Wang, Guijun,Senanayake, Chris H.
supporting information, p. 2474 - 2477 (2013/03/28)
A general, efficient, and highly diastereoselective method for the synthesis of structurally and sterically diverse P-chiral phosphine oxides was developed. The method relies on sequential nucleophilic substitution on the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide, which features enhanced and differentiated P-N and P-O bond reactivity toward nucleophiles. The reactivities of both bonds are fine-tuned to allow cleavage to occur even with sterically hindered nucleophiles under mild conditions.
