1421845-49-9Relevant academic research and scientific papers
Selectivity control by silver catalysts in the cycloisomerization of 1,6-enynes derived from propiolamides
Koo, Jaeyoung,Park, Hyun-Sub,Shin, Seunghoon
supporting information, p. 834 - 839 (2013/02/25)
Silver-catalyzed cycloisomerizations of 1,6-enynes derived from propiolamides led to a selective formation of Alder-ene type 1,4-dienes. Interestingly, AgNTf2 outperformed gold or platinum catalysts in terms of selectivity and reactivity, providing the 1,4-dienes at room temperature. The presence of C(5) carbonyl group in combination with Ag salts is key to the selectivity and the β-oxo coordinated silver carbenoids were proposed as an intermediate based on the reaction profiles.
