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Ciguatoxin-2 (CTX-2) is a potent neurotoxin derived from certain species of dinoflagellates, marine microorganisms that produce this heat-stable toxin. CTX-2 accumulates in the tissues of herbivorous reef fish, such as barracuda and snapper, which can be consumed by humans. It is characterized by its ability to bind to voltage-gated sodium channels in nerve cells, disrupting their function and leading to gastrointestinal and neurological symptoms in humans. Due to its heat stability and the difficulty in detecting it through smell or taste, CTX-2 poses a significant risk of foodborne poisoning, which can be life-threatening in severe cases. Currently, there is no specific antidote for CTX-2, and management of exposure primarily involves supportive care and symptom management.

142185-85-1

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142185-85-1 Usage

Uses

Used in Research and Development:
CTX-2 is used as a research tool for studying the effects of neurotoxins on voltage-gated sodium channels and their role in nerve cell function. Understanding the mechanism of action of CTX-2 can contribute to the development of potential treatments and antidotes for ciguatera fish poisoning.
Used in Public Health and Food Safety:
CTX-2 serves as a critical biomarker for monitoring and assessing the risk of ciguatera fish poisoning in seafood. Detecting the presence of CTX-2 in fish can help prevent the consumption of contaminated seafood, reducing the incidence of foodborne illness and protecting public health.
Used in Environmental Monitoring:
CTX-2 can be used as an indicator of the presence of harmful dinoflagellate species in marine ecosystems. Monitoring the levels of CTX-2 in seawater can provide insights into the distribution and abundance of these microorganisms, which can inform environmental management strategies and help predict potential outbreaks of ciguatera fish poisoning.
Used in Pharmaceutical Development:
Although CTX-2 is a potent neurotoxin, its unique mechanism of action on voltage-gated sodium channels may offer potential therapeutic applications. Researchers are exploring the possibility of developing modified forms of CTX-2 or related compounds that could be used as targeted treatments for specific neurological disorders or as tools for studying ion channel function in drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 142185-85-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,1,8 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 142185-85:
(8*1)+(7*4)+(6*2)+(5*1)+(4*8)+(3*5)+(2*8)+(1*5)=121
121 % 10 = 1
So 142185-85-1 is a valid CAS Registry Number.
InChI:InChI=1/C60H86O18/c1-29-22-42-44(25-48-54(75-42)31(3)52(64)58-55(76-48)30(2)32(4)60(78-58)20-9-21-66-60)72-46-27-51-59(5,77-47(46)23-29)50(63)26-45-36(73-51)12-7-6-11-35-37(70-45)16-17-39-38(68-35)18-19-40-43(69-39)24-49-57(74-40)53(65)56-41(71-49)13-8-10-34(67-56)15-14-33(62)28-61/h6-8,10,14-19,29-58,61-65H,9,11-13,20-28H2,1-5H3/b7-6+,15-14+/t29-,30+,31+,32+,33+,34-,35-,36+,37+,38+,39-,40-,41+,42+,43+,44-,45-,46+,47-,48+,49-,50-,51-,52+,53-,54-,55-,56+,57-,58+,59+,60+/m1/s1

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