142187-35-7Relevant academic research and scientific papers
Iridium-catalyzed asymmetric allylic etherification and ring-closing metathesis reaction for enantioselective synthesis of chromene and 2,5-dihydrobenzo[b]oxepine derivatives
He, Hu,Ye, Ke-Yin,Wu, Qing-Feng,Dai, Li-Xin,You, Shu-Li
experimental part, p. 1084 - 1094 (2012/05/20)
Iridium-catalyzed asymmetric etherifications of allylic carbonates with 2-vinylphenols and 2-allylphenols were realized. With a catalyst generated from 2mol% of [Ir(cod)Cl]2 (cod=cycloocta-1,5-diene) and 4mol% of the phosphoramidite ligand L2, the etherification products were obtained in excellent ees and then subjected to the ring-closing metathesis reaction providing an efficient synthesis of enantioenriched 2H-chromene and 2,5-dihydrobenzo[b]oxepine derivatives. Copyright
Enantioselective synthesis of chromanes by iridium-catalyzed asymmetric hydrogenation of 4H-chromenes
Valla, Carine,Baeza, Alejandro,Menges, Frederik,Pfaltz, Andreas
experimental part, p. 3167 - 3171 (2009/06/17)
Iridium complexes of chiral oxazoline-based P,N-ligands proved to be efficient catalysts for the enantioselective hydrogenation of 2-aryl- and 2-alkyl-4H-chromenes. The best results were obtained with a ligand derived from threonine (ThrePHOX), which induced ee values of 95% to >99% in the hydrogenation of 2-methyl-, 2-cyclohexyl- and various 2-aryl-substituted chromenes. Georg Thieme Verlag Stuttgart.
