1421920-52-6

Upstream product

• 62584-30-9 4-chloro-3,5-bis(trifluoromethyl)benzonitrile 

Downstream Products

• 1421920-53-7 4-chloro-3,5-bis(trifluoromethyl)benzothioamide 
• 1421920-54-8 3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole 
• 1421923-98-9 (Z)-isopropyl 3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate 
• 1421923-99-0 (Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid 
• 1421923-92-3 C₁₇H₁₀ClF₆N₇O 

Relevant academic research and scientific papers

HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.