1421925-59-8

Upstream product

• 1421925-45-2 8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-1-one 
• 1421925-58-7 8-methyl-3-phenyl-2H-benzo[b][1,6]naphthyridin-1-one 
• 1421925-43-0 C₂₁H₁₇NO₂ 
• 1421925-44-1 C₂₃H₂₁NO₂ 
• 73568-27-1 2-chloro-6-methylquinoline-3-carbaldehyde 
• 1100050-99-4 6-methyl-2-(phenylethynyl)quinoline-3-carbaldehyde 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

Iodine mediated: In situ generation of R-Se-I: Application towards the construction of pyrano[4,3- b] quinoline heterocycles and fluorescence properties

In this paper, we report the iodine mediated in situ generation of R-Se-I and further its application towards the construction of pyrano[4,3-b]quinolin-1-one derivatives. The structural elaboration of 1-chloro-8-methyl-3-phenylbenzo[b][1,6]naphthyridine 6 was successfully achieved by Sonogashira, Suzuki coupling and dehalogenation reactions. Finally, the synthesized compounds 4a, 5a, 5b, 6, and 7a-7c were studied for photophysical properties including UV-absorption, fluorescence, and quantum yield studies. The synthesized pyranoquinoline derivatives showed λmax, Fmax and Φf values in the range of 391-447 nm, 436-486 nm and 0.004-0.301, respectively in chloroform solvent.

An economical nucleophilic route toward facile synthesis of pyrano[4,3-b]quinolin-1-ones via 6-endo-dig cyclization of o-alkynylquinoline esters

Metal-free facile synthesis of pyrano[4,3-b]quinoline-1-ones is described from methyl 2-arylethynylquinoline-3-carboxylates via intramolecular cyclization in excellent yields. The cyclization reactions are facilitated using cheap and easily available KOH base in MeOH. The reaction conditions did not require dry solvent, inert atmosphere, and avoid further column chromatography purification of the products. These compounds could be further used as building blocks for the synthesis of 2H-benzo[b][1,6]naphthyridin-1-one and 1-chloro-benzo[b][1,6] naphthyridines.