Mal-PEG3-alcohol is a PEGylated molecule that features a maleimide group and a hydroxyl group. It is characterized by a hydrophilic PEG (polyethylene glycol) spacer that enhances solubility in aqueous environments. The hydroxyl group allows for additional chemical modifications or the attachment of other reactive functional groups, while the maleimide group is capable of forming a covalent bond with a thiol group, facilitating the conjugation of biomolecules with thiol moieties.
1421933-37-0
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Basic information
- Product Name: Mal-PEG3-alcohol
- Synonyms: Mal-PEG3-alcohol;Mal-PEG4-OH;Mal-PEG4;Mal-PEG4-alcohol
- CAS NO:1421933-37-0
- Molecular Formula: C12H19NO6
- Molecular Weight: 273.28236
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1421933-37-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 427.9±35.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.246±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO, DCM, DMF
- PKA: 14.36±0.10(Predicted)
- CAS DataBase Reference: Mal-PEG3-alcohol(CAS DataBase Reference)
- NIST Chemistry Reference: Mal-PEG3-alcohol(1421933-37-0)
- EPA Substance Registry System: Mal-PEG3-alcohol(1421933-37-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1421933-37-0(Hazardous Substances Data)
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1421933-37-0 Usage
Uses
Used in Pharmaceutical Industry:Mal-PEG3-alcohol is used as a PEGylation agent for improving the pharmacokinetic properties of therapeutic biomolecules. The PEGylation process increases the solubility, stability, and circulation time of the biomolecule in the body, reducing immunogenicity and proteolytic degradation.
Used in Drug Delivery Systems:
In the field of drug delivery, Mal-PEG3-alcohol serves as a versatile component for the development of targeted drug delivery systems. The maleimide group can be used to attach drug molecules or targeting ligands containing thiol groups, enabling site-specific drug delivery and reducing systemic side effects.
Used in Bioconjugation:
Mal-PEG3-alcohol is used as a bioconjugation agent for the covalent attachment of biomolecules, such as proteins, peptides, or nucleic acids, to other molecules or surfaces. This can be useful for the development of biosensors, immobilized enzymes, or antibody-drug conjugates.
Used in Material Science:
In material science, Mal-PEG3-alcohol can be utilized to modify surfaces or create hydrogels with tunable properties. The PEG spacer and maleimide group provide opportunities for the controlled assembly of multifunctional materials with enhanced biocompatibility and responsiveness to environmental stimuli.
Check Digit Verification of cas no
The CAS Registry Mumber 1421933-37-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,9,3 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.Calculate Digit Verification of CAS Registry Number 1421933-37:
(9*1)+(8*4)+(7*2)+(6*1)+(5*9)+(4*3)+(3*3)+(2*3)+(1*7)=140
140 % 10 = 0
So 1421933-37-0 is a valid CAS Registry Number.
1421933-37-0Upstream product
1421933-37-0Downstream Products
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Mal-PEG3-alcohol
