1421960-16-8

Basic information

• Product Name: C₁₇H₂₇N₃O₈
• Synonyms: C₁₇H₂₇N₃O₈
• CAS NO: 1421960-16-8
• Molecular Weight: 401.417
• Mol File: 1421960-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₇N₃O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₇N₃O₈(1421960-16-8)
• EPA Substance Registry System: C₁₇H₂₇N₃O₈(1421960-16-8)

Safety Data

• Hazardous Substances Data: 1421960-16-8(Hazardous Substances Data)

Upstream product

• 498-95-3 (R)-nipecotic acid 

Relevant articles and documents

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors

In order to exploit the 430-cavity in the active sites of neuraminidases, 22 zanamivir analogs with C-1 and C-4 modification were synthesized, and their inhibitory activities against both group-1 (H5N1, H1N1) and group-2 neuraminidases (H3N2) were determined. Compound 9f exerts the most potency, with IC50 value of 0.013, 0.001, and 0.09 μM against H3N2, H5N1, and H1N1, which is similar to that of zanamivir (H3N2 IC50 = 0.0014 μM, H5N1 IC50 = 0.012 μM, H1N1 IC50 = 0.001 μM). Pharmacokinetic studies of compound 9f in rats showed a much longer plasma half-life (t1/2) than that of zanamivir following administration (po dose). Molecular modeling provided information about the binding model between the new inhibitors and neuraminidase, with the elongated groups at the C-1-position being projected toward the 430-loop region. This study may represent a novel starting point for the future development of improved antiflu agents.