1422012-11-0Relevant academic research and scientific papers
Thermal, non-catalyzed Huisgen cycloaddition for the preparation of 4,5-bis(trimethylsilyl)-1H-1,2,3-triazoles
Brisbois, Ronald G.,Bergan, Alexandra M.,Ellison, Aubrey J.,Griffin, Percy Y.,Hackbarth, Kent C.,Larson, Steven R.
, p. 272 - 276 (2013)
The 1,2,3-triazole scaffold is an important pharmacophore and a versatile, increasingly leveraged, substructure in biochemical, materials, polymer, and metal-coordinating applications. Continuing advances in 1,2,3-triazole construction, by either non-catalyzed or metal-catalyzed azide/alkyne cycloaddition, foster further creative use. The work reported here establishes a general protocol for the synthesis of 4,5-bis(trimethylsilyl)-1H-1,2,3- triazoles via thermal Huisgen cycloaddition between azides and bis(trimethylsilyl)acetylene.
