1422017-30-8Relevant academic research and scientific papers
[Silver(I)(Pyridine-Containing Ligand)] Complexes as unusual catalysts for A3-coupling reactions
Trose, Michael,Dell'Acqua, Monica,Pedrazzini, Tommaso,Pirovano, Valentina,Gallo, Emma,Rossi, Elisabetta,Caselli, Alessandro,Abbiati, Giorgio
, p. 7311 - 7320 (2014/09/16)
Two original macrocyclic silver(I)(pyridine-containing ligand) complexes [Ag(I)(Pc-L)] were synthesized and characterized. Their ability to catalyze the coupling among aldehydes, terminal alkynes and amines (A3-coupling) was demonstrated. The reaction could be performed under conventional as well as dielectric heating. The catalysts were effective in both cases, but dielectric heating allowed a lower catalyst loading and reduced ratio among reaction partners in shorter reaction times. The reaction scope was broad, including aryl/alkyl aldehydes, aryl/alkyl acetylenes and secondary aliphatic amines. Some unprecedented propargylamines have been prepared. The new catalytic system was also tested with more challenging coupling partners such as aniline and ketones.
Asymmetric cyclopropanation of olefins catalysed by Cu(i) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*)
Castano, Brunilde,Guidone, Stefano,Gallo, Emma,Ragaini, Fabio,Casati, Nicola,MacChi, Piero,Sisti, Massimo,Caselli, Alessandro
supporting information, p. 2451 - 2462 (2013/03/28)
The synthesis and characterisation of copper(i) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*) and their use as catalysts in asymmetric cyclopropanation reactions are reported. All ligands and metal complexes were fully characterised, including crystal structures of some species determined by X-ray diffraction on single crystals. This allowed characterising the very different conformations of the macrocycles which could be induced by different substituents or by metal complexation. The strategy adopted for the ligand synthesis is very flexible allowing several structural modifications. A small library of macrocyclic ligands possessing the same donor properties but with either C1 or C2 symmetry was synthesized. Cyclopropane products with both aromatic and aliphatic olefins were obtained in good yields and enantiomeric excesses up to 99%.
