142209-40-3

Basic information

• Product Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methoxybenzamide
• Synonyms: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methoxybenzamide
• CAS NO: 142209-40-3
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.36364
• Mol File: 142209-40-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methoxybenzamide(142209-40-3)
• EPA Substance Registry System: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-methoxybenzamide(142209-40-3)

Safety Data

• Hazardous Substances Data: 142209-40-3(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 21615-34-9 2-Methoxybenzoyl chloride 

Relevant articles and documents

Josiphos-Type Binaphane Ligands for Iridium-Catalyzed Enantioselective Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines

Convenient synthesis and useful application of a series of Josiphos-type binaphane ligands were described. The iridium complexes of these chiral diphosphines displayed excellent enantioselectivity and good reactivity in the asymmetric hydrogenation of challenging 1-aryl-substituted dihydroisoquinoline substrates (full conversions, up to >99% ee, 4000 TON). The use of 40% HBr (aqueous solution) as an additive dramatically improved the asymmetric induction of these catalysts. This transformation provided a highly efficient and enantioselective access to chiral 1-aryl-substituted tetrahydroisoquinolines, which were of great importance and common in natural products and biologically active molecules.

Synthesis and spectral properties of 6,7-dimethoxy-1-[(ortho; and para-R)-phenyl]-3,4-dihydroisoquinoline

The preparation of eleven novel 6,7-dimethoxy-1-[(ortho, and para-R)-phenyl]-3,4-dihydroisoquinolines with possible pharmacological activity is described. The structure of all products was corroborated by ir, 1H nmr, 13C-nmr, and ms.