1422165-27-2Relevant academic research and scientific papers
Aminocatalytic asymmetric exo-Diels-Alder reaction with methiodide salts of Mannich bases and 2,4-dienals to construct chiral spirocycles
Zhang, Shan-Jun,Zhang, Jun,Zhou, Qing-Qing,Dong, Lin,Chen, Ying-Chun
supporting information, p. 968 - 971 (2013/03/29)
An asymmetric exo-Diels-Alder reaction of α-methylene carbonyl compounds, generated in situ from stable methiodide salts of Mannich bases, with 2,4-dienals, has been developed through trienamine activation of a chiral secondary amine. A spectrum of spirocyclanes with high molecular complexity was efficiently constructed in moderate to excellent diastereo- and enantioselectivity.
