1422191-90-9Relevant academic research and scientific papers
Drug delivery with a calixpyrrole-trans -Pt(II) complex
Cafeo, Grazia,Carbotti, Grazia,Cuzzola, Angela,Fabbi, Marina,Ferrini, Silvano,Kohnke, Franz H.,Papanikolaou, Georgia,Plutino, Maria Rosaria,Rosano, Camillo,White, Andrew J. P.
supporting information, p. 2544 - 2551 (2013/03/29)
A meso-p-nitroaniline-calix[4]pyrrole derivative trans-coordinated to a Pt(II) center was synthesized and its structure solved by X-ray analysis. Adenosine monophosphate (AMP) was used as a model compound to evaluate the potential for the assisted delivery of the metal to the DNA nucleobases via the phosphate anion-binding properties of the calix[4]pyrrole unit. An NMR investigation of the kinetics of AMP complexation in the absence of an H-bonding competing solvent (dry CD3CN) was consistent with this hypothesis, but we could not detect the interaction of the calix[4]pyrrole with phosphate in the presence of water. However, in vitro tests of the new trans-calixpyrrole- Pt(II) complex on different cancer cell lines indicate a cytotoxic activity that is unquestionably derived from the coexistence of both the trans-Pt(II) fragment and the calix[4]pyrrole unit.
