1422251-53-3Relevant articles and documents
Mono- and trifluorination of the thiazole ring of 2,5-diarylthiazoles using N-fluorobenzenesulfonimide (NFSI)
Hatfield, Julie M.,Eidell, Cheryl K.,Stephens, Chad E.
, p. 1025 - 1028 (2013/02/25)
Fluorination of select 2,5-diarylthiazoles using the N-F reagent N-fluorobenzenesulfonimide (NFSI) has led to the formation of both the anticipated 4-fluorothiazole as well as a unique 4,4,5-trifluorothiazole. Selective monofluorination is best achieved using bromobenzene as solvent at 155 °C, while trifluorination is best achieved by performing the reaction without solvent at 135-140 °C. An X-ray crystal structure has been obtained on one of the trifluorinated products.