142229-07-0Relevant academic research and scientific papers
Mild Michael addition of glycine imines to aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive
Li, Wei,Liu, Han,Du, Da-Ming
, p. 925 - 928 (2009)
A mild Michael addition of glycine imines to aromatic-nitroalkenes catalyzed by 10 mol% DBU with LiOTf as an additive was developed. In most cases, the products could be obtained in good yields (up to 96%) with moderate to good diastereoselectivities (up
Diastereo- And enantioselective synthesis of α,γ-diaminobutyric acid derivatives via Cu-catalyzed asymmetric michael reaction
Li, Qing,Ding, Chang-Hua,Hou, Xue-Long,Dai, Li-Xin
scheme or table, p. 1080 - 1083 (2010/06/15)
(Figure Presented) The first highly diastereo- and enantioselective catalytic asymmetric Michael addition of glycine derivatives to nitroalkenes have been developed. The enantioselectivity of ortho-substituted products can be significantly improved by using a new 1,2-P,N-ferrocene ligand L5. The α,γdiaminoacid derivative was obtained without the loss of optical activity from the adduct.
Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).
Rowley, Michael,Leeson, Paul D.,Williams, Brian J.,Moore, Kevin W.,Baker, Raymond
, p. 3557 - 3570 (2007/10/02)
Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to
