1422352-46-2Relevant academic research and scientific papers
Water promoted one pot three-component synthesis of tetrazoles
Sathishkumar, Murugan,Shanmugavelan, Poovan,Nagarajan, Sangaraiah,Dinesh, Murugan,Ponnuswamy, Alagusundaram
, p. 488 - 493 (2013)
A one pot, three component synthesis of tetrazoles via thiourea has been accomplished in water. Water enhances the solubility of a higher number of components in the three component protocol thus promoting the reaction. The synthesis involves a chemoselective exocyclic reaction, regioselective electrocyclisation and a preferred conformational orientation of the tetrazole side chain which are rationalised based on the relative magnitude of Garbisch angle strain/allylic strains anticipated during the course of the reaction.
