1422463-69-1

Basic information

• Product Name: ethyl 4-oxo-1-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)cyclohex-2-enecarboxylate
• Synonyms: ethyl 4-oxo-1-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)cyclohex-2-enecarboxylate
• CAS NO: 1422463-69-1
• Molecular Weight: 328.481
• Mol File: 1422463-69-1.mol

Chemical Properties

• CAS DataBase Reference: ethyl 4-oxo-1-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)cyclohex-2-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-oxo-1-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)cyclohex-2-enecarboxylate(1422463-69-1)
• EPA Substance Registry System: ethyl 4-oxo-1-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)cyclohex-2-enecarboxylate(1422463-69-1)

Safety Data

• Hazardous Substances Data: 1422463-69-1(Hazardous Substances Data)

Upstream product

• 1422463-72-6 ethyl 2-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)prop-2-enoate 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 10029-04-6 ethyl 2-(hydroxymethyl)acrylate 

Relevant articles and documents

Microwave-assisted Diels-Alder reactions between Danishefsky's diene and derivatives of ethyl α-(hydroxymethyl)acrylate. Synthetic approach toward a biotinylated anti-inflammatory monocyclic cyanoenone

The microwave heating drastically accelerates Diels-Alder cycloadditions between Danishefsky's diene and derivatives of ethyl α-(hydroxymethyl) acrylate whose hydroxyl group is protected with various protective groups to give previously unknown adducts, which are necessary as intermediates for the synthesis of a biotin conjugate of a monocyclic cyanoenone with high anti-inflammatory activity. The reaction time is only 1 h and the average yield is approximately 80%. Compared to the traditional thermal conditions this method requires 1/48th to 1/14th of the time and the yields are 2-7 times more.