1422464-41-2Relevant academic research and scientific papers
Photoregulating catalytic activity of cyclodextrin-based artificial glutathione peroxidase by charged azobenzene
Wu, Ping,Xiao, Ruiqing,Zhang, Chunqiu,Zhou, Lipeng,Luo, Quan,Xu, Jiayun,Liu, Junqiu
, p. 62 - 67 (2010)
Modulating the activities of enzymes by using an external signal is widely used for many applications. In this paper, it has been performed for the first time that photoregulating the activity of artificial glutathione peroxidase (GPx) by using photocontrolled inclusion-exclusion reaction of the azobenzene with two typical GPx mimics, the telluride β-Cyclodextrin (β-CD) dimmer and the ditelluride β-CD dimmer. The activities of both mimics were differently inhibited by either cationic or anionic azobenzene, owing to the catalytic capacity variance of the telluride moieties of the mimics and the different strength of the electrostatic interactions between the charges of the substrates and the azobenzenes. The inclusion of the anionic azobenzene with the ditelluride β-CD dimmer represented the largest inhibition rate. When the inclusion was irradiated upon UV light, the activity recovered, whereas inhibited again upon visible light. Such process could be repeated many times and a switchable artificial enzyme based on the reaction was proposed. Graphical Abstract: It was performed that photoregulating artificial enzyme by using photocontroled inclusion-exclusion reaction of one 6-ditellurium β-CD dimmer with two anionic azobenzenes. When inclusion underwent the activity of the artificial enzyme was inhibited. After irradiation with UV light, the cis-isomer azobenzene formed, and went away from the cavity left an appropriate cavity for accommodating a substrate, as a result, the activity recovered. After irradiation with visible light, the activity was inhibited over again, owing to that the trans-isomer azobenzene regenerated, and regressed to the inclusion. Such process could be repeated many times.
Light-triggered capture and release of DNA and proteins by host-guest binding and electrostatic interaction
Moratz, Johanna,Samanta, Avik,Voskuhl, Jens,Nalluri, Siva Krishna Mohan,Ravoo, Bart Jan
supporting information, p. 3271 - 3277 (2015/03/05)
The development of an effective and general delivery method that can be applied to a large variety of structurally diverse biomolecules remains a bottleneck in modern drug therapy. Herein, we present a supramolecular system for the dynamic trapping and li
Photoresponsive vesicle permeability based on intramolecular host-guest inclusion
Kauscher, Ulrike,Samanta, Avik,Ravoo, Bart Jan
supporting information, p. 600 - 606 (2014/01/06)
This article describes light-responsive vesicles that can release their contents in response to a light-sensitive molecular trigger. To this end, liposomes were equipped with amphiphilic β-cyclodextrin that was covalently labeled with azobenzene. Using dy
Biocatalytic amide condensation and gelation controlled by light
Sahoo, Jugal Kishore,Nalluri, Siva Krishna Mohan,Javid, Nadeem,Webb, Hannah,Ulijn, Rein V.
supporting information, p. 5462 - 5464 (2014/05/20)
We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed
