142247-99-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 142276-42-4 [3-((1R,2R)-2-Hydroxy-1-hydroxymethyl-propylcarbamoyl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 116821-47-7 N-(9-fluorenylmethyloxycarbonyl)-4-aminobutyric acid 

Downstream Products

• 770711-67-6 N-{(1R,2R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-4-(2-methoxy-6-nitro-acridin-9-ylamino)-butyramide 
• 850589-21-8 N-{(1R,2R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-4-(6-chloro-2-methoxy-acridin-9-ylamino)-butyramide 

Relevant academic research and scientific papers

Crucial role of linker portion in acridine-bearing oligonucleotides for highly efficient site-selective RNA scission

Through a series of linkers, 9-amino-2-methoxy-6-nitroacridine and 9-amino-6-chloro-2-methoxyacridine were tethered to the middle of oligonucleotide, and the abilities of these conjugates for site-selective activation of RNA (inducing site-selective sciss