1422470-13-0Relevant academic research and scientific papers
A PIM kinase inhibitors of hydrochloride and its preparation and use (by machine translation)
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Paragraph 0055; 0056; 0057; 0058; 0059, (2018/01/13)
The invention relates to a hydrochloride of PIM kinase inhibitors and its preparation method and use thereof, wherein the PIM kinase inhibitors of acid salt having a structure of formula (II) is shown. The hydrochloric acid salt has higher solubility, good stability, high bioavailability, very low hygroscopicity, and to PIM kinase has good inhibition activity. (by machine translation)
PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF
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Paragraph 0190; 0191; 0240; 0241, (2014/06/24)
PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds as represented by Formula I. The compounds significantly inhibit the P
