14225-81-1

Basic information

• Product Name: 2-(2-chloro-5-fluorophenyl)-1H-benzimidazole
• CAS NO: 14225-81-1
• Molecular Formula: C₁₃H₈ClFN₂
• Molecular Weight: 246.6674
• Mol File: 14225-81-1.mol

Chemical Properties

• Boiling Point: 430.2°C at 760 mmHg
• Flash Point: 214°C
• Density: 1.397g/cm³
• Vapor Pressure: 1.32E-07mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 2-(2-chloro-5-fluorophenyl)-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloro-5-fluorophenyl)-1H-benzimidazole(14225-81-1)
• EPA Substance Registry System: 2-(2-chloro-5-fluorophenyl)-1H-benzimidazole(14225-81-1)

Safety Data

• Hazardous Substances Data: 14225-81-1(Hazardous Substances Data)

Usage

Chemical class

Benzimidazole

Structure

Benzene ring fused to an imidazole ring

Substituents

Chlorine atom on the benzene ring, fluorine atom at position 5 on the benzene ring

Biological activities

Antiparasitic, antimicrobial

Preclinical studies

Anti-inflammatory, anti-tumor

Potential applications

Drug-discovery research, new pharmaceuticals development

Upstream product

• 202522-23-4 2-chloro-5-fluorobenzylamine 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

A heterogeneous catalytic strategy for facile production of benzimidazoles and quinoxalines from primary amines using the Al-MCM-41 catalyst

This study reports a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize nitrogen heterocycle moieties from primary amines under solvent-free conditions. The Al-MCM-41 catalyst was prepared using a hydrothermal method and characterized by various analytical techniques. The probability and limitations of the catalytic methodology were presented with various substrates. The catalytic method grants an attractive route to a wide variety of benzimidazole and quinoxaline moieties with good to excellent yields. The gram scale reaction and reusability (up to five cycles) of the Al-MCM-41 catalyst would greatly benefit industrial applications. This journal is