1422527-47-6Relevant articles and documents
Rapid preparation of mycobacterium N-glycolyl lipid i and lipid II derivatives: A biocatalytic approach
Chen, Kuo-Ting,Kuan, Ye-Ching,Fu, Wei-Chen,Liang, Pi-Hui,Cheng, Ting-Jen R.,Wong, Chi-Huey,Cheng, Wei-Chieh
, p. 834 - 838 (2013/02/25)
Breaking down barriers: A rapid, inexpensive preparation of the structurally complex mycobacterial N-glycolyl LipidI, LipidII, and their analogues from a range of different synthetic N-glycolyl and N-glycinyl Park's nucleotides is described (see scheme). The biotransformations were catalyzed by a readily available biocatalyst obtained from a bacterial cell-free membrane fraction. The unnatural N-glycinyl LipidII was found to be a substrate of Mycobacterium tuberculosis (Mtb) transglycosylase, PonA, and N-glycolyl LipidI was a weak inhibitor against PonA. Copyright