1422528-08-2Relevant academic research and scientific papers
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
Yaziji, Vicente,Rodriguez, David,Coelho, Alberto,Garcia-Mera, Xerardo,El Maatougui, Abdelaziz,Brea, Jose,Loza, Maria Isabel,Cadavid, Maria Isabel,Gutierrez-De-Teran, Hugo,Sotelo, Eddy
, p. 235 - 242 (2013/03/13)
The influence of diverse methoxyphenyl substitution patterns on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold is herein explored in order to modulate the A3 adenosine receptor antagonistic profile. As a result, novel ligands exhibiting excellent potency (Ki on A3 AR 3AR selectivity, first established by a robust computational model and thereafter characterizing the most salient features of the structure-activity and structure-selectivity relationships in this series.
