1422538-40-6

Basic information

• Product Name: C₄₆H₅₇N₇O₇
• CAS NO: 1422538-40-6
• Molecular Weight: 820.001
• Mol File: 1422538-40-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₅₇N₇O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₅₇N₇O₇(1422538-40-6)
• EPA Substance Registry System: C₄₆H₅₇N₇O₇(1422538-40-6)

Safety Data

• Hazardous Substances Data: 1422538-40-6(Hazardous Substances Data)

Upstream product

• 1422538-30-4 (2R,4S)-benzyl 2-tert-butyl-5-oxo-4-(2-oxoethyl)-4-((1-(triisopropylsilyl)-1H-indol-3-yl)methyl)oxazolidine-3-carboxylate 
• 1422538-29-1 (2R,4R)-benzyl 4-allyl-2-tert-butyl-5-oxo-4-((1-(triisopropylsilyl)-1H-indol-3-yl)methyl)oxazolidine-3-carboxylate 
• 1422538-28-0 (2R,4R)-benzyl 2-tert-butyl-5-oxo-4-((1-(triisopropylsilyl)-1H-indol-3-yl)methyl)oxazolidine-3-carboxylate 
• 1422538-27-9 (R)-2-amino-3-(1-(triisopropylsilyl)-1H-indol-3-yl)propanoic acid 
• 1422538-43-9 C₃₄H₅₆N₄O₅Si 
• 1422538-26-8 (R)-methyl 2-amino-3-(1-(triisopropylsilyl)-1H-indol-3-yl)propanoate 
• 1422538-25-7 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(1-(triisopropylsilyl)-1H-indol-3-yl)propanoate 
• 151872-21-8 (R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 1422538-38-2 tert-butyl ((S)-6-(methylamino)-6-oxo-5-((S)-2′-oxo-1,2,4,9-tetrahydrospiro[pyrido[3,4-b]indole-3,3′-pyrrolidin]-1′-yl)hexyl)carbamate 
• 10030-31-6 (S)-2-((S)-2-acetamido-3-phenylpropanamido)-3-phenylpropanoic acid 
• 1422538-37-1 (S)-methyl 6-((tert-butoxycarbonyl)amino)-2-((S)-2′-oxo-1,2,4,9-tetrahydrospiro[pyrido[3,4-b]indole-3,3′-pyrrolidin]-1′-yl)hexanoate 
• 1422538-36-0 (S)-methyl 2-((S)-3-((1H-indol-3-yl)methyl)-3-amino-2-oxopyrrolidin-1-yl)-6-((tert-butoxycarbonyl)amino)hexanoate 
• 1422538-35-9 (S)-methyl 2-((S)-3-(((benzyloxy)carbonyl)amino)-2-oxo-3-((1-(triisopropylsilyl)-1H-indol-3-yl)methyl)pyrrolidin-1-yl)-6-((tert-butoxycarbonyl)amino)hexanoate 

Relevant articles and documents

Tetrahydro-β-carboline-based spirocyclic lactam as type II′ β-turn: Application to the synthesis and biological evaluation of somatostatine mimetics

The synthesis of novel spirocyclic lactams, embodying d-tryptophan (Trp) amino acid as the central core and acting as peptidomimetics, is presented. It relies on the strategic combination of Seebach's self-reproduction of chirality chemistry and Pictet-Spengler condensation as key steps. Investigation of the conformational behavior by molecular modeling, X-ray crystallography, and NMR and IR spectroscopies suggests very stable and highly predictable type II′ β-turn conformations for all compounds. Relying on this feature, we also pursued their application to two potential mimetics of the hormone somatostatin, a pharmaceutically relevant natural peptide, which contains a Trp-based type II′ β-turn pharmacophore.