1422554-34-4

Basic information

• Product Name: BET-IN-1
• Synonyms: BET-IN-1
• CAS NO: 1422554-34-4
• Molecular Formula: C25H30N4O4
• Molecular Weight: 450.5301
• Mol File: 1422554-34-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BET-IN-1(CAS DataBase Reference)
• NIST Chemistry Reference: BET-IN-1(1422554-34-4)
• EPA Substance Registry System: BET-IN-1(1422554-34-4)

Safety Data

• Hazardous Substances Data: 1422554-34-4(Hazardous Substances Data)

Usage

General Description

BET-IN-1 is a chemical compound that belongs to the class of BET bromodomain inhibitors, which are being explored for their potential therapeutic use in various diseases, including cancer and inflammatory conditions. BET-IN-1 specifically targets the BET family of bromodomain-containing proteins, which play a key role in the regulation of gene expression through the recognition of acetylated lysine residues on chromatin. By inhibiting these proteins, BET-IN-1 has shown promising effects in preclinical studies, including suppression of tumor growth and inflammation. BET-IN-1 has garnered interest as a potential drug candidate for the treatment of diseases involving dysregulated gene expression and aberrant inflammation. Further research is underway to investigate the full therapeutic potential and safety profile of BET-IN-1.

Upstream product

• 1300031-66-6 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-nitro-4-quinolinol 
• 1300031-58-6 7-(3,5-dimethyl-4-isoxazolyl)-4-hydroxy-6-(methyloxy)-3-quinolinecarboxylic acid 
• 1300031-67-7 7-(3,5-dimethylisoxazol-4-yl)-6-methoxyquinolin-4-ol 
• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 1403491-43-9 7-(3,5-dimethyl-4-isoxazolyl)-N⁴-[1-methyl-2-(methyloxy)ethyl]-6-(methyloxy)-3,4-quinolinediamine 
• 1403491-42-8 7-(3,5-dimethyl-4-isoxazolyl)-N-[1-methyl-2-(methyloxy)ethyl]-6-(methyloxy)-3-nitro-4-quinolinamine 
• 1300031-65-5 4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline 
• 1422554-33-3 4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole 
• 1422554-32-2 N-(7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-4-((1-methoxypropan-2-yl)amino)quinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide 

Relevant articles and documents

Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression

The functions of the bromodomain and extra terminal (BET) family of proteins have been implicated in a wide range of diseases, particularly in the oncology and immuno-inflammatory areas, and several inhibitors are under investigation in the clinic. To mitigate the risk of attrition of these compounds due to structurally related toxicity findings, additional molecules from distinct chemical series were required. Here we describe the structure- and property-based optimization of the in vivo tool molecule I-BET151 toward I-BET282E, a molecule with properties suitable for progression into clinical studies.

4-(8-METHOXY-1-((1-METHOXYPROPAN-2-YL)-2-(TETRAHYDRO-2H-PYRAN-4-YL)-1 H-IMIDAZO[4,5-C]QUINOLIN-7-YL)-3,5-DIMETHYLISOXAZOLE AND ITS USE AS BROMODOMAIN INHIBITOR

Novel quinoline compounds of formula (I), pharmaceutical compositions containing such compounds and their use in therapy, as bromodomain inhibitors.