142274-09-7

Basic information

• Product Name: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate
• Synonyms: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate
• CAS NO: 142274-09-7
• Molecular Weight: 215.249
• Mol File: 142274-09-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate(142274-09-7)
• EPA Substance Registry System: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate(142274-09-7)

Safety Data

• Hazardous Substances Data: 142274-09-7(Hazardous Substances Data)

Upstream product

• 142274-08-6 (4-ethoxy-1,5-dihydro-2-oxo-2H-pyrrol-1-yl)acetic acid 
• 142274-11-1 2,4-dioxopyrrolidin-1-yl-acetic acid 
• 71-36-3 butan-1-ol 

Downstream Products

• 68252-28-8 oxiracetam 

Relevant articles and documents

Synthesis method of oxiracetam

The invention relates to a synthesis method of (S)-oxiracetam. The method comprises the following steps: (1) carrying out an esterification reaction on alcohol and S-4-amino-3-hydroxybutyrate taken as a starting material to obtain an intermediate I; (2) enabling the intermediate I and halogenated acetic ester to be subjected to a condensation reaction to obtain an intermediate II; (3) carrying out a ring closing reaction on the intermediate II to obtain an intermediate III; and (4) carrying out an ammonolysis reaction on the intermediate III to obtain the target product (S)-oxiracetam. After the synthesis route of the oxiracetam is adopted, the (S)-oxiracetam with more ideal yield of 20% or more is at least obtained; and therefore, a new oxiracetam synthesis route is opened up.

An efficient synthesis of racemic 4-hydroxy-2-oxo-1-pyrrolidineacetamide (oxiracetam) using tetramic-acid intermediates

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