142285-31-2

Upstream product

• 142285-16-3 methyl (1R,S)-2-oxo-1-pentylcyclooctanecarboxylate 
• 126908-92-7 (2S,9R)-9-Pentyl-oxonane-2-carbaldehyde 
• 126908-88-1 (2R^*,9S^*)-2-hydroxymethyl-9-pentyloxonane 
• 126908-86-9 9-(R,S)-pentyloxonan-2-one 
• 126908-87-0 2-Methylene-9-pentyl-oxonane 
• 126908-85-8 2-(R,S)-pentylcyclooctanone 
• 5452-73-3 methyl 2-oxocyclooctanecarboxylate 
• 502-49-8 cycloactanone 
• 126908-88-1 (2S^*,9S^*)-2-hydroxymethyl-9-pentyloxonane 
• 99-33-2 3,5-dinitrobenoyl chloride 

Relevant academic research and scientific papers

Synthesis of Medium Ring Ethers. Part 2. Synthesis of the Fully Saturated Carbon Skeleton of Laurencia Non-terpenoid Ether Metabolites Containing Seven-, Eight- and Nine-membered Rings

A general method for the construction of medium ring ethers is described in which a 2-substituted cycloalkanone was subjected to a Baeyer-Villiger ring expansion to the lactone, Tebbe methylenation of which afforded the enol ether which was subjected to a hydroboration-oxidation sequence to afford the 2,n-disubstituted oxacycle (n = ring size).Application of this procedure has led to efficient syntheses of the fully saturated skeletons corresponding to the naturally occurring Laurencia metabolites containing 2,n-dialkyl substituted seven- (isolaurepan), eight- (lauthisan and laurenan) and nine-membered (obtusan) ethers.