142285-73-2Relevant academic research and scientific papers
Synthesis, antihypertensive and α-adrenoceptor activity of novel 2-aminoalkyl-3(2H)-pyridazinones
Matyus,Kosary,Kasztreiner,Makk,Diesler,Czako,Rabloczky,Jaszlits,Horvath,Tomoskozi,Cseh,Horvath,Aranyi
, p. 107 - 114 (2007/10/02)
A number of 2-phenoxyalkylaminoalkyl- and 2-[1,4]benzodioxanylmethylaminoalkyl-3(2H)-pyridazinones were synthesized and tested for hypotensive and antihypertensive activity as well as for α1- and α2-adrenoceptor binding affinities. S
3(2H)-pyridazinones and pharmaceutical compositions thereof
-
, (2008/06/13)
The invention relates to novel 3(2H)-pyridazinone-derivatives of the general formula (I), pharmaceutical compositions containing them and process for their preparation. In the general formula (I) STR1 stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR1 R2 group, wherein R1 represents hydrogen atom or an unsubstituted or optionally substituted benzyl group; R2 represents hydrogen atom or an unsubstituted or optionally substituted benzo[1,4]dioxan-2-yl-methyl or -ethyl group or a (CH2)n --R3 group, wherein n is 2 or 3; and R3 stands for an unsubstituted or optionally substituted phenoxy or phenylthio group; and X stands for a hydrogen or halogen atom or an unsubstituted or optionally substituted, saturated or unsaturated 5- or 6-membered heterocyclic group containing a nitrogen atom and optionally an additional heteroatom, e.g. an oxygen, sulfur or nitrogen atom, with the proviso that R is different from an ethyl or propyl group substituted terminally by a hydroxyl group or halogen atom when X represents a hydrogen or chlorine atom. The compounds of general formula (I) selectively inhibit the adrenergic alpha1 receptors, have a calcium-antagonistic effect and exert blood pressure lowering action.
3(2H)-pyridazinone derivatives, a process and intermediates for preparing them and medicaments containing them and/or other 3(2H)-pyridazinone derivatives
-
, (2008/06/13)
The subject-matter of the invention are 3(2H)-Pyridazinone derivatives of the general formula wherein R stands for an ethyl or propyl group substituted by a terminal halogen atom or hydroxyl group or a terminal group of the formula in which latter R? represents a hydrogen atom or an optionally substituted benzyl group and R? represents a hydrogen atom or an optionally substituted benzo[1,4]dioxan-2-yl-methyl or benzo[1,4]dioxan-2-yl-ethyl group or a group of the formula in which latter n is 2 or 3 and R? stands for an optionally substituted phenoxy or phenylthio group and X stands for a hydrogen or halogen atom or an optionally substituted saturated or unsaturated 5-or 6-membered heterocyclic group.Furthermore the subject-matter of the invention are a process and intermediates for preparing these compounds and medicaments containing them and/or other 3(2H)-pyridazinone derivatives.The compounds according to the invention inhibit the adrenergic alpha? receptors, have a calcium--antagonistic effect and exert blood pressure lowering action.
