1422955-39-2

Basic information

• Product Name: C₁₂H₇ClFN₃O
• Synonyms: C₁₂H₇ClFN₃O
• CAS NO: 1422955-39-2
• Molecular Weight: 263.658
• Mol File: 1422955-39-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₂H₇ClFN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₇ClFN₃O(1422955-39-2)
• EPA Substance Registry System: C₁₂H₇ClFN₃O(1422955-39-2)

Safety Data

• Hazardous Substances Data: 1422955-39-2(Hazardous Substances Data)

Upstream product

• 4863-91-6 3-chloro-5-fluoroaniline 
• 19155-86-3 5-chlorobenzo[c][1,2,5]oxadiazole 

Relevant articles and documents

INHIBITION OF HIF-2α HETERODIMERIZATION WITH HIF1β (ARNT)

Provided is a method of inhibiting heterodimerization of HIF-2α to HIF1β (ARNT) comprising binding certain small molecules to the HIF-2α PAS-B domain cavity but not to HIF1α and inhibiting HIF-2α heterodimerization to HIF1β (ARNT) but not inhibiting HIF1α

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity relationship study of small molecules designed to inhibit HIF-2α-ARNT heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain. Through a series of biophysical characterizations of inhibitor-protein interactions (NMR and X-ray crystallography), we have established the structural requirements for artificial inhibitors of the HIF-2α-ARNT PAS-B interaction. These results may serve as a foundation for discovering therapeutic agents that function by a novel mode of action.