1422962-07-9

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 14542-93-9 1,1,3,3-tetramethylbutane isonitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 100-46-9 benzylamine 

Downstream Products

• 1422962-09-1 2-benzyl-3-(4-chlorophenyl)isoindolin-1-one 

Relevant academic research and scientific papers

Facile synthesis of diverse isoindolinone derivatives via Ugi-4CR followed by Cu-catalyzed deamidative C(sp2)-C(sp3) coupling

The present work highlights a synthetic approach to the diverse isoindolinone derivatives using Ugi-4CR followed by a Cu-catalyzed deamidative C-C coupling reaction. This two-step sequence tolerates a broad range of amines, aldehydes, and isocyanides as starting materials for Ugi-4CR products to provide medicinally relevant isoindolinone derivatives in moderate to good yields.