1422963-22-1Relevant articles and documents
Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells
Chen, Jinying,Ma, Liang,Zhang, Ronghong,Tang, Jie,Lai, Huijun,Wang, Jun,Wang, Guangcheng,Xu, Qinyuan,Chen, Tao,Peng, Fei,Qiu, Jingxiang,Liang, Xiaolin,Cao, Dong,Ran, Yan,Peng, Aihua,Wei, Yuquan,Chen, Lijuan
, p. 945 - 956 (2013/02/22)
A series of 4β-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin congeners were synthesized by employing click chemistry and further evaluated for their antitumor activity by MTT assay. Among them, six congeners (10, 11, 12, 13, 22, and 24) exhibited ap