1422964-01-9Relevant academic research and scientific papers
Auto-tandem catalysis: Synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition-aerobic dehydrogenation-intramolecular amidation
Yang, Yan,Shu, Wen-Ming,Yu, Shang-Bo,Ni, Fan,Gao, Meng,Wu, An-Xin
, p. 1729 - 1731 (2013)
A copper-catalyzed domino synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from 1,4-enediones and 2-aminoheterocycles with air as the oxidant. The Royal Society of Chemistry 2013.
Heterogeneous Cu/OMS-2 as an efficient catalyst for the synthesis of tetrasubstituted 1,4-enediones and 4H-pyrido[1,2-a]-pyrimidin-4-ones
Zhang, Jinqi,Meng, Xu,Yu, Chaoying,Chen, Gexin,Zhao, Peiqing
, p. 87221 - 87227 (2015/11/09)
An efficient Cu/OMS-2-catalyzed oxidative heterogeneous protocol has been developed for the synthesis of tetrasubstituted unsymmetrical 1,4-enediones and 4H-pyrido[1,2-a]-pyrimidin-4-ones from 1,4-enediones and amines or 2-aminopyridines. The present catalytic system employs air as the terminal oxidant and tolerates a broad range of substrates using low loading copper (1.3 wt%). The Cu/OMS-2 was characterized by various methods, including XRD, XPS, BET as well as TEM/SEM, and the results of H2-TPR shows that the redox ability of the catalyst was improved by the combination of Cu and OMS-2. Moreover, the catalyst is recyclable.
