1422968-33-9Relevant academic research and scientific papers
Benzosulfones as photochemically activated sulfur dioxide (SO2) donors
Malwal, Satish R.,Chakrapani, Harinath
, p. 2399 - 2406 (2015)
Sulfur dioxide (SO2) is a gaseous environmental pollutant which is routinely used in industry as a preservative and antimicrobial. Recent data suggests that SO2 may have value as a therapeutic agent. However, due to its gaseous nature, localizing SO2 generation is challenging. Herein, various 1,3-dihydrobenzo[c]thiophene 2,2-dioxides (benzosulfones) were prepared as candidates for photochemically activated sulfur dioxide (SO2) generation. These compounds were found to be stable in buffer but were photolysed upon irradiation with UV light to generate SO2. Our data indicates that photolysis of benzosulfones depends on substituents, and that the presence of electron donating groups results in an enhanced yield of SO2. This journal is
Benzosultines as sulfur dioxide (SO2) donors
Malwal, Satish R.,Gudem, Mahesh,Hazra, Anirban,Chakrapani, Harinath
, p. 1116 - 1119 (2013/04/23)
In order to understand precise biological roles of sulfur dioxide (SO 2), reliable SO2 donors, compounds that produce SO 2 under physiological conditions, are necessary. The design and development of 1-phenyl-benzosultine as an efficient SO2 donor is reported. This compound undergoes cycloreversion to generate SO2 upon dissolution in aqueous buffer at 37 C with a yield of 89% and a half-life of 39 min and shows SO2-like biological activity in a DNA cleavage assay.
