1422984-95-9Relevant academic research and scientific papers
Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?
Dias, David M.,Van Molle, Inge,Baud, Matthias G. J.,Galdeano, Carles,Geraldes, Carlos F. G. C.,Ciulli, Alessio
, p. 23 - 28 (2014/02/14)
Modulation of protein-protein interactions (PPIs) with small molecules has been hampered by a lack of lucid methods capable of reliably identifying high-quality hits. In fragment screening, the low ligand efficiencies associated with PPI target sites pose
