1422984-99-3Relevant academic research and scientific papers
3-nitro-2-phenyl-2-(Trifluoromethyl)-2h-chromenes: Synthesis and reactions with nucleophiles
Barkov, Alexey Yu.,Korotaev, Vladislav Yu.,Kotovich, Ivan V.,Zimnitskiy, Nikolai S.,Kutyashev, Igor B.,Sosnovskikh, Vyacheslav Ya.
, p. 814 - 822 (2016)
A method is proposed for the synthesis of 3-nitro-2-phenyl-2-(trifluoromethyl)-2H-chromenes by tandem condensation of salicylic aldehydes with (E)-3,3,3-trifluoro-1-nitro-2-phenylprop-1-ene in the presence of triethylamine. The example of 3-nitro-2-phenyl
Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction
Bao, Robert Li-Yuan,Fu, Kang,Shi, Lei
supporting information, (2021/11/27)
A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.
Access to Chiral GABA Analogues Bearing a Trifluoromethylated All-Carbon Quaternary Stereogenic Center through Water-Promoted Organocatalytic Michael Reactions
Sim, Jae Hun,Park, Jin Hyun,Maity, Pintu,Song, Choong Eui
supporting information, p. 6715 - 6719 (2019/10/02)
Water enables the highly challenging enantioselective Michael addition of sterically congested β-trifluoromethyl-β-aryl- or -alkyl-substituted nitroolefins with dithiomalonates. Under on-water conditions, the reaction rates were remarkably accelerated as
The squaramide-catalyzed asymmetric Michael/cyclization tandem reaction for the synthesis of chiral trifluoromethylated hydroxyimino tetrahydrobenzofuranones
Liu, Wei,Lai, Xiaoyan,Zha, Gaofeng,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
supporting information, p. 3603 - 3607 (2016/04/19)
An enantioselective synthesis of trifluoromethylated hydroxyimino tetrahydrobenzofuranones has been developed. 1,3-Dicarbonyl carbocyclic compounds react with β-CF3-β-disubstituted nitroalkenes in the presence of a chiral squaramide catalyst, p
Enantioselective Michael Addition of Pyrazolin-5-ones to β-CF3-β-Disubstituted Nitroalkenes Catalyzed by Squaramide Organocatalyst
Lai, Xiaoyan,Zha, Gaofeng,Liu, Wei,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
supporting information, p. 1983 - 1988 (2016/08/09)
A highly enantioselective Michael addition of pyrazolin-5-ones with β-CF3-β-disubstituted nitroalkenes catalyzed by bifunctional squaramide has been developed. Various chiral β-CF3-β-5-hydroxy-pyrazolin-3-yl-disubstituted nitroalkane derivatives bearing all-carbon quaternary stereocenter were prepared in good yields (up to 88%) and excellent enantioselectivities (up to 97% ee).
Enantioselective organocatalytic reduction of β-trifluoromethyl nitroalkenes: An efficient strategy for the synthesis of chiral β-trifluoromethyl amines
Massolo, Elisabetta,Benaglia, Maurizio,Orlandi, Manuel,Rossi, Sergio,Celentano, Giuseppe
supporting information, p. 3589 - 3595 (2015/03/04)
An efficient organocatalytic stereoselective reduction of β-trifluoromethyl-substituted nitroalkenes, mediated by 3,5-dicarboxylic ester-dihydropyridines (Hantzsch ester type), has been successfully developed. A multifunctional thiourea-based (S)-valine d
Highly enantioselective construction of trifluoromethylated all-carbon quaternary stereocenters via nickel-catalyzed friedel-crafts alkylation reaction
Gao, Jian-Rong,Wu, Hao,Xiang, Bin,Yu, Wu-Bin,Han, Liang,Jia, Yi-Xia
supporting information, p. 2983 - 2986 (2013/04/10)
A highly enantioselective Friedel-Crafts alkylation reaction of indoles with β-CF3-β-disubstituted nitroalkenes was achieved using a Ni(ClO4)2-bisoxazoline complex as a catalyst, which afforded indole-bearing chiral compou
