142301-65-3

Basic information

• Product Name: Acetamide, 2,2,2-trifluoro-N-(phenylmethyl)-N-2-propenyl-
• CAS NO: 142301-65-3
• Molecular Formula: C12H12F3NO
• Molecular Weight: 243.229
• Mol File: 142301-65-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trifluoro-N-(phenylmethyl)-N-2-propenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-(phenylmethyl)-N-2-propenyl-(142301-65-3)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-(phenylmethyl)-N-2-propenyl-(142301-65-3)

Safety Data

• Hazardous Substances Data: 142301-65-3(Hazardous Substances Data)

Upstream product

• 7387-69-1 N-benzyl-2,2,2-trifluoroacetamide 
• 106-95-6 allyl bromide 
• 68003-55-4 benzylidene allylamine 
• 4383-22-6 Allylbenzylamine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 347195-55-5 (R)-1-benzyl-3-ethylpiperazine 
• 674283-98-8 piperazinone 
• 142301-66-4 N-benzyl-2,2,2-trifluoro-N-(2-oxoethyl)acetamide 

Relevant articles and documents

Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GS

Heterocycles in Asymmetric Synthesis. Part 1. Construction of the Chiral Building Blocks for Enantioselective Alkaloid Synthesis via an Asymmetric Intramolecular Michael Reaction

The asymmetric intramolecular Michael reaction of acyclic compounds ethyl (E)-4-but-2-enoate 9, and ethyl (E)-5-pent-2-enoate 10 was investigated under a variety of conditions, and the pyrrolidine ethyl (4-acetyl-1-benzylpyrrolidin-3-yl)acetate 11 and piperidine ethyl (3-acetyl-1-benzylpiperidin-4-yl)acetate 12, versatile chiral building blocks for alkaloid synthesis, were obtained in moderate to excellent optical yield.Cyclization of the aforementioned but- and pent-2-enoate using (R)-1-phenylethylamine in THF in the presence of molecular sieves 5 Angstroem gave the (+)-pyrrolidine derivative (+)-11 and the (-)-piperidine derivative (-)-12 in 60 and 90percent ee, respectively.When (S)-1-phenylethylamine was used, pyrrolidine (-)-11 and piperidine derivatives (+)-12 were obtained in similar optical yields, respectively.The ee of (-)- and (+)-piperidine derivatives increased up to 98percent upon recrystallization of their hydrobromid salts.