142301-65-3Relevant academic research and scientific papers
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors
Kohara, Toshiyuki,Nakayama, Kazuki,Watanabe, Kazutoshi,Kusaka, Shin-ichi,Sakai, Daiki,Tanaka, Hiroshi,Fukunaga, Kenji,Sunada, Shinji,Nabeno, Mika,Saito, Ken-Ichi,Eguchi, Jun-ichi,Mori, Akiko,Tanaka, Shinji,Bessho, Tomoko,Takiguchi-Hayashi, Keiko,Horikawa, Takashi
, p. 3733 - 3738 (2017/07/27)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GS
Photo-induced intramolecular arene-olefin meta-cycloaddition of 5-phenyl-fluorinated-pent-1-enes
Guo, Xiao-Chuan,Chen, Qing-Yun
, p. 149 - 156 (2007/10/03)
A series of fluorinated angular and linear triquinanes and their aza-analogues have been synthesized by photo-induced intramolecular meta-cycloaddition of 5-phenyl-fluorinated-pent-1-enes.
Heterocycles in Asymmetric Synthesis. Part 1. Construction of the Chiral Building Blocks for Enantioselective Alkaloid Synthesis via an Asymmetric Intramolecular Michael Reaction
Hirai, Yoshiro,Terada, Takashi,Yamazaki, Takao,Momose, Takefumi
, p. 509 - 516 (2007/10/02)
The asymmetric intramolecular Michael reaction of acyclic compounds ethyl (E)-4-but-2-enoate 9, and ethyl (E)-5-pent-2-enoate 10 was investigated under a variety of conditions, and the pyrrolidine ethyl (4-acetyl-1-benzylpyrrolidin-3-yl)acetate 11 and piperidine ethyl (3-acetyl-1-benzylpiperidin-4-yl)acetate 12, versatile chiral building blocks for alkaloid synthesis, were obtained in moderate to excellent optical yield.Cyclization of the aforementioned but- and pent-2-enoate using (R)-1-phenylethylamine in THF in the presence of molecular sieves 5 Angstroem gave the (+)-pyrrolidine derivative (+)-11 and the (-)-piperidine derivative (-)-12 in 60 and 90percent ee, respectively.When (S)-1-phenylethylamine was used, pyrrolidine (-)-11 and piperidine derivatives (+)-12 were obtained in similar optical yields, respectively.The ee of (-)- and (+)-piperidine derivatives increased up to 98percent upon recrystallization of their hydrobromid salts.
