1423030-10-7Relevant articles and documents
Effective palladium-catalyzed hydroxycarbonylation of aryl halides with substoichiometric carbon monoxide
Korsager, Signe,Taaning, Rolf H.,Skrydstrup, Troels
, p. 2891 - 2894 (2013)
A protocol for the Pd-catalyzed hydroxycarbonylation of aryl iodides, bromides, and chlorides has been developed using only 1-5 mol % of CO, corresponding to a pCO as low as 0.1 bar. Potassium formate is the only stoichiometric reagent, acting as a mildly basic nucleophile and a reservoir of CO. The substoichiometric CO could be delivered to the reaction from an acyl-Pd(II) precatalyst, which provides both the CO and an active catalyst, and thereby obviates the need for handling a toxic gas.