142310-30-3Relevant academic research and scientific papers
Hydrogenolysis of 1-Aminopyrazoles: Synthesis of Primary and Secondary Alkylamines
Adembri, G.,Camparini, A.,Ponticelli, F.,Scotton, M.
, p. 321 - 326 (2007/10/02)
The tautomerizable N-aminopyrazolone 9, the O-methyl 1 and N-methyl derivatives 4 were condensed with carbonyl compounds to give the alkenylaminopyrazoles 12, 2a-g and 5c, wich, under mild conditions, were hydrogenated to the corresponding alkylamino derivatives.The subesquent hydrogenation of the latter ones gave different results according to the structure of the starting material.The 5-methoxy-1-alkylaminopyrazoles 3a-g yielded the 5-methoxypyrazole 15 and the corresponding primary amines in good yields.On the contrary, N-methyl-1-alkylaminopyrazolone-5 6c gave 1-a lkylpyrazolone-3 8.
